Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
Identifieur interne : 000313 ( Main/Exploration ); précédent : 000312; suivant : 000314Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
Auteurs : Shun Li [États-Unis, République populaire de Chine] ; Ying Song [États-Unis] ; Christine Quach [États-Unis] ; Hongrui Guo [États-Unis, République populaire de Chine] ; Gyu-Beom Jang [États-Unis] ; Hadi Maazi [États-Unis] ; Shihui Zhao [États-Unis] ; Nathaniel A. Sands [États-Unis] ; Qingsong Liu [République populaire de Chine] ; Gino K. In [États-Unis] ; David Peng [États-Unis] ; Weiming Yuan [États-Unis] ; Keigo Machida [États-Unis] ; Min Yu [États-Unis] ; Omid Akbari [États-Unis] ; Ashley Hagiya [États-Unis] ; Yongfei Yang [États-Unis] ; Vasu Punj [États-Unis] ; Liling Tang [République populaire de Chine] ; Chengyu Liang [États-Unis]Source :
- Nature Communications [ 2041-1723 ] ; 2019.
Abstract
Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAFV600E-melanoma, autophagy is induced by BRAF inhibitor (BRAFi), as part of a transcriptional program coordinating lysosome biogenesis/function, mediated by the TFEB transcription factor. TFEB is phosphorylated and thus inactivated by BRAFV600E via its downstream ERK independently of mTORC1. BRAFi disrupts TFEB phosphorylation, allowing its nuclear translocation, which is synergized by increased phosphorylation/inactivation of the ZKSCAN3 transcriptional repressor by JNK2/p38-MAPK. Blockade of BRAFi-induced transcriptional activation of autophagy-lysosomal function in melanoma xenografts causes enhanced tumor progression, EMT-transdifferentiation, metastatic dissemination, and chemoresistance, which is associated with elevated TGF-β levels and enhanced TGF-β signaling. Inhibition of TGF-β signaling restores tumor differentiation and drug responsiveness in melanoma cells. Thus, the “BRAF-TFEB-autophagy-lysosome” axis represents an intrinsic regulatory pathway in BRAF-mutant melanoma, coupling BRAF signaling with TGF-β signaling to drive tumor progression and chemoresistance.
Url:
DOI: 10.1038/s41467-019-09634-8
PubMed: 30979895
PubMed Central: 6461621
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000136
- to stream Pmc, to step Curation: 000136
- to stream Pmc, to step Checkpoint: 000277
- to stream Ncbi, to step Merge: 000537
- to stream Ncbi, to step Curation: 000537
- to stream Ncbi, to step Checkpoint: 000537
- to stream Main, to step Merge: 000313
- to stream Main, to step Curation: 000313
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance</title><author><name sortKey="Li, Shun" sort="Li, Shun" uniqKey="Li S" first="Shun" last="Li">Shun Li</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0154 0904</institution-id><institution-id institution-id-type="GRID">grid.190737.b</institution-id><institution>Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering,</institution><institution>Chongqing University,</institution></institution-wrap>Chongqing, 400044 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chongqing</wicri:regionArea></affiliation></author><author><name sortKey="Song, Ying" sort="Song, Ying" uniqKey="Song Y" first="Ying" last="Song">Ying Song</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Quach, Christine" sort="Quach, Christine" uniqKey="Quach C" first="Christine" last="Quach">Christine Quach</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Guo, Hongrui" sort="Guo, Hongrui" uniqKey="Guo H" first="Hongrui" last="Guo">Hongrui Guo</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0185 3134</institution-id><institution-id institution-id-type="GRID">grid.80510.3c</institution-id><institution>College of Veterinary Medicine,</institution><institution>Sichuan Agriculture University,</institution></institution-wrap>Chengdu, 611130 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chengdu</wicri:regionArea></affiliation></author><author><name sortKey="Jang, Gyu Beom" sort="Jang, Gyu Beom" uniqKey="Jang G" first="Gyu-Beom" last="Jang">Gyu-Beom Jang</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Maazi, Hadi" sort="Maazi, Hadi" uniqKey="Maazi H" first="Hadi" last="Maazi">Hadi Maazi</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Zhao, Shihui" sort="Zhao, Shihui" uniqKey="Zhao S" first="Shihui" last="Zhao">Shihui Zhao</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Sands, Nathaniel A" sort="Sands, Nathaniel A" uniqKey="Sands N" first="Nathaniel A." last="Sands">Nathaniel A. Sands</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Liu, Qingsong" sort="Liu, Qingsong" uniqKey="Liu Q" first="Qingsong" last="Liu">Qingsong Liu</name><affiliation wicri:level="3"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution>High Magnetic Field Laboratory,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>350 Shushan Hu Road, Hefei, 230031 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>350 Shushan Hu Road, Hefei</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="In, Gino K" sort="In, Gino K" uniqKey="In G" first="Gino K." last="In">Gino K. In</name><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Norris Comprehensive Cancer, Division of Oncology,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Peng, David" sort="Peng, David" uniqKey="Peng D" first="David" last="Peng">David Peng</name><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Dermatology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Yuan, Weiming" sort="Yuan, Weiming" uniqKey="Yuan W" first="Weiming" last="Yuan">Weiming Yuan</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Machida, Keigo" sort="Machida, Keigo" uniqKey="Machida K" first="Keigo" last="Machida">Keigo Machida</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Yu, Min" sort="Yu, Min" uniqKey="Yu M" first="Min" last="Yu">Min Yu</name><affiliation wicri:level="2"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Akbari, Omid" sort="Akbari, Omid" uniqKey="Akbari O" first="Omid" last="Akbari">Omid Akbari</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Hagiya, Ashley" sort="Hagiya, Ashley" uniqKey="Hagiya A" first="Ashley" last="Hagiya">Ashley Hagiya</name><affiliation wicri:level="2"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Pathology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Yang, Yongfei" sort="Yang, Yongfei" uniqKey="Yang Y" first="Yongfei" last="Yang">Yongfei Yang</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Punj, Vasu" sort="Punj, Vasu" uniqKey="Punj V" first="Vasu" last="Punj">Vasu Punj</name><affiliation wicri:level="2"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Pathology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Medicine, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Tang, Liling" sort="Tang, Liling" uniqKey="Tang L" first="Liling" last="Tang">Liling Tang</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0154 0904</institution-id><institution-id institution-id-type="GRID">grid.190737.b</institution-id><institution>Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering,</institution><institution>Chongqing University,</institution></institution-wrap>Chongqing, 400044 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chongqing</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Chengyu" sort="Liang, Chengyu" uniqKey="Liang C" first="Chengyu" last="Liang">Chengyu Liang</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30979895</idno><idno type="pmc">6461621</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461621</idno><idno type="RBID">PMC:6461621</idno><idno type="doi">10.1038/s41467-019-09634-8</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000136</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000136</idno><idno type="wicri:Area/Pmc/Curation">000136</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000136</idno><idno type="wicri:Area/Pmc/Checkpoint">000277</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000277</idno><idno type="wicri:Area/Ncbi/Merge">000537</idno><idno type="wicri:Area/Ncbi/Curation">000537</idno><idno type="wicri:Area/Ncbi/Checkpoint">000537</idno><idno type="wicri:Area/Main/Merge">000313</idno><idno type="wicri:Area/Main/Curation">000313</idno><idno type="wicri:Area/Main/Exploration">000313</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance</title><author><name sortKey="Li, Shun" sort="Li, Shun" uniqKey="Li S" first="Shun" last="Li">Shun Li</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0154 0904</institution-id><institution-id institution-id-type="GRID">grid.190737.b</institution-id><institution>Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering,</institution><institution>Chongqing University,</institution></institution-wrap>Chongqing, 400044 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chongqing</wicri:regionArea></affiliation></author><author><name sortKey="Song, Ying" sort="Song, Ying" uniqKey="Song Y" first="Ying" last="Song">Ying Song</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Quach, Christine" sort="Quach, Christine" uniqKey="Quach C" first="Christine" last="Quach">Christine Quach</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Guo, Hongrui" sort="Guo, Hongrui" uniqKey="Guo H" first="Hongrui" last="Guo">Hongrui Guo</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0185 3134</institution-id><institution-id institution-id-type="GRID">grid.80510.3c</institution-id><institution>College of Veterinary Medicine,</institution><institution>Sichuan Agriculture University,</institution></institution-wrap>Chengdu, 611130 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chengdu</wicri:regionArea></affiliation></author><author><name sortKey="Jang, Gyu Beom" sort="Jang, Gyu Beom" uniqKey="Jang G" first="Gyu-Beom" last="Jang">Gyu-Beom Jang</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Maazi, Hadi" sort="Maazi, Hadi" uniqKey="Maazi H" first="Hadi" last="Maazi">Hadi Maazi</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Zhao, Shihui" sort="Zhao, Shihui" uniqKey="Zhao S" first="Shihui" last="Zhao">Shihui Zhao</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Sands, Nathaniel A" sort="Sands, Nathaniel A" uniqKey="Sands N" first="Nathaniel A." last="Sands">Nathaniel A. Sands</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Liu, Qingsong" sort="Liu, Qingsong" uniqKey="Liu Q" first="Qingsong" last="Liu">Qingsong Liu</name><affiliation wicri:level="3"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution>High Magnetic Field Laboratory,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>350 Shushan Hu Road, Hefei, 230031 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>350 Shushan Hu Road, Hefei</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="In, Gino K" sort="In, Gino K" uniqKey="In G" first="Gino K." last="In">Gino K. In</name><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Norris Comprehensive Cancer, Division of Oncology,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Peng, David" sort="Peng, David" uniqKey="Peng D" first="David" last="Peng">David Peng</name><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Dermatology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Yuan, Weiming" sort="Yuan, Weiming" uniqKey="Yuan W" first="Weiming" last="Yuan">Weiming Yuan</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Machida, Keigo" sort="Machida, Keigo" uniqKey="Machida K" first="Keigo" last="Machida">Keigo Machida</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Yu, Min" sort="Yu, Min" uniqKey="Yu M" first="Min" last="Yu">Min Yu</name><affiliation wicri:level="2"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Akbari, Omid" sort="Akbari, Omid" uniqKey="Akbari O" first="Omid" last="Akbari">Omid Akbari</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Hagiya, Ashley" sort="Hagiya, Ashley" uniqKey="Hagiya A" first="Ashley" last="Hagiya">Ashley Hagiya</name><affiliation wicri:level="2"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Pathology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Yang, Yongfei" sort="Yang, Yongfei" uniqKey="Yang Y" first="Yongfei" last="Yang">Yongfei Yang</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Punj, Vasu" sort="Punj, Vasu" uniqKey="Punj V" first="Vasu" last="Punj">Vasu Punj</name><affiliation wicri:level="2"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Pathology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Medicine, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Tang, Liling" sort="Tang, Liling" uniqKey="Tang L" first="Liling" last="Tang">Liling Tang</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0154 0904</institution-id><institution-id institution-id-type="GRID">grid.190737.b</institution-id><institution>Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering,</institution><institution>Chongqing University,</institution></institution-wrap>Chongqing, 400044 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chongqing</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Chengyu" sort="Liang, Chengyu" uniqKey="Liang C" first="Chengyu" last="Liang">Chengyu Liang</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Molecular Microbiology and Immunology, Keck School of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Los Angeles</wicri:cityArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAF<sup>V600E</sup>-melanoma, autophagy is induced by BRAF inhibitor (BRAFi), as part of a transcriptional program coordinating lysosome biogenesis/function, mediated by the TFEB transcription factor. TFEB is phosphorylated and thus inactivated by BRAF<sup>V600E</sup> via its downstream ERK independently of mTORC1. BRAFi disrupts TFEB phosphorylation, allowing its nuclear translocation, which is synergized by increased phosphorylation/inactivation of the ZKSCAN3 transcriptional repressor by JNK2/p38-MAPK. Blockade of BRAFi-induced transcriptional activation of autophagy-lysosomal function in melanoma xenografts causes enhanced tumor progression, EMT-transdifferentiation, metastatic dissemination, and chemoresistance, which is associated with elevated TGF-β levels and enhanced TGF-β signaling. Inhibition of TGF-β signaling restores tumor differentiation and drug responsiveness in melanoma cells. Thus, the “BRAF-TFEB-autophagy-lysosome” axis represents an intrinsic regulatory pathway in BRAF-mutant melanoma, coupling BRAF signaling with TGF-β signaling to drive tumor progression and chemoresistance.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rubinsztein, Dc" uniqKey="Rubinsztein D">DC Rubinsztein</name></author><author><name sortKey="Codogno, P" uniqKey="Codogno P">P Codogno</name></author><author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holderfield, M" uniqKey="Holderfield M">M Holderfield</name></author><author><name sortKey="Deuker, Mm" uniqKey="Deuker M">MM Deuker</name></author><author><name sortKey="Mccormick, F" uniqKey="Mccormick F">F McCormick</name></author><author><name sortKey="Mcmahon, M" uniqKey="Mcmahon M">M McMahon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, X" uniqKey="Xie X">X Xie</name></author><author><name sortKey="Koh, Jy" uniqKey="Koh J">JY Koh</name></author><author><name sortKey="Price, S" uniqKey="Price S">S Price</name></author><author><name sortKey="White, E" uniqKey="White E">E White</name></author><author><name sortKey="Mehnert, Jm" uniqKey="Mehnert J">JM Mehnert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="He, Z" uniqKey="He Z">Z He</name></author><author><name sortKey="Simon, Hu" uniqKey="Simon H">HU Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flaherty, Kt" uniqKey="Flaherty K">KT Flaherty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, Xh" uniqKey="Ma X">XH Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanduja, S" uniqKey="Sanduja S">S Sanduja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Settembre, C" uniqKey="Settembre C">C Settembre</name></author><author><name sortKey="Medina, Dl" uniqKey="Medina D">DL Medina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martina, Ja" uniqKey="Martina J">JA Martina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Settembre, C" uniqKey="Settembre C">C Settembre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martina, Ja" uniqKey="Martina J">JA Martina</name></author><author><name sortKey="Puertollano, R" uniqKey="Puertollano R">R Puertollano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Settembre, C" uniqKey="Settembre C">C Settembre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chauhan, S" uniqKey="Chauhan S">S Chauhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsai, J" uniqKey="Tsai J">J Tsai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joseph, Ew" uniqKey="Joseph E">EW Joseph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, C" uniqKey="Sun C">C Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wagle, N" uniqKey="Wagle N">N Wagle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Urano, J" uniqKey="Urano J">J Urano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jewell, Jl" uniqKey="Jewell J">JL Jewell</name></author><author><name sortKey="Russell, Rc" uniqKey="Russell R">RC Russell</name></author><author><name sortKey="Guan, Kl" uniqKey="Guan K">KL Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bar Peled, L" uniqKey="Bar Peled L">L Bar-Peled</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palmieri, M" uniqKey="Palmieri M">M Palmieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perera, Rm" uniqKey="Perera R">RM Perera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Medina, Dl" uniqKey="Medina D">DL Medina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Napolitano, G" uniqKey="Napolitano G">G Napolitano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doble, Bw" uniqKey="Doble B">BW Doble</name></author><author><name sortKey="Woodgett, Jr" uniqKey="Woodgett J">JR Woodgett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alessi, Dr" uniqKey="Alessi D">DR Alessi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brady, Dc" uniqKey="Brady D">DC Brady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohori, M" uniqKey="Ohori M">M Ohori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martina, Ja" uniqKey="Martina J">JA Martina</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Gucek, M" uniqKey="Gucek M">M Gucek</name></author><author><name sortKey="Puertollano, R" uniqKey="Puertollano R">R Puertollano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogakou, Ep" uniqKey="Rogakou E">EP Rogakou</name></author><author><name sortKey="Pilch, Dr" uniqKey="Pilch D">DR Pilch</name></author><author><name sortKey="Orr, Ah" uniqKey="Orr A">AH Orr</name></author><author><name sortKey="Ivanova, Vs" uniqKey="Ivanova V">VS Ivanova</name></author><author><name sortKey="Bonner, Wm" uniqKey="Bonner W">WM Bonner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Degenhardt, K" uniqKey="Degenhardt K">K Degenhardt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alexaki, Vi" uniqKey="Alexaki V">VI Alexaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiery, Jp" uniqKey="Thiery J">JP Thiery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacomin, Ac" uniqKey="Jacomin A">AC Jacomin</name></author><author><name sortKey="Samavedam, S" uniqKey="Samavedam S">S Samavedam</name></author><author><name sortKey="Promponas, V" uniqKey="Promponas V">V Promponas</name></author><author><name sortKey="Nezis, Ip" uniqKey="Nezis I">IP Nezis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seglen, Po" uniqKey="Seglen P">PO Seglen</name></author><author><name sortKey="Gordon, Pb" uniqKey="Gordon P">PB Gordon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuzu, Of" uniqKey="Kuzu O">OF Kuzu</name></author><author><name sortKey="Nguyen, Fd" uniqKey="Nguyen F">FD Nguyen</name></author><author><name sortKey="Noory, Ma" uniqKey="Noory M">MA Noory</name></author><author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nazarian, R" uniqKey="Nazarian R">R Nazarian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lamouille, S" uniqKey="Lamouille S">S Lamouille</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Derynck, R" uniqKey="Derynck R">R Derynck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Villanueva, J" uniqKey="Villanueva J">J Villanueva</name></author><author><name sortKey="Vultur, A" uniqKey="Vultur A">A Vultur</name></author><author><name sortKey="Herlyn, M" uniqKey="Herlyn M">M Herlyn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perna, D" uniqKey="Perna D">D Perna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greger, Jg" uniqKey="Greger J">JG Greger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunen, D" uniqKey="Brunen D">D Brunen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fang, L" uniqKey="Fang L">L Fang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, C" uniqKey="Zeng C">C Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, S" uniqKey="Jin S">S Jin</name></author><author><name sortKey="White, E" uniqKey="White E">E White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karantza Wadsworth, V" uniqKey="Karantza Wadsworth V">V Karantza-Wadsworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mathew, R" uniqKey="Mathew R">R Mathew</name></author><author><name sortKey="Karantza Wadsworth, V" uniqKey="Karantza Wadsworth V">V Karantza-Wadsworth</name></author><author><name sortKey="White, E" uniqKey="White E">E White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mathew, R" uniqKey="Mathew R">R Mathew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, L" uniqKey="Cheng L">L Cheng</name></author><author><name sortKey="Lopez Beltran, A" uniqKey="Lopez Beltran A">A Lopez-Beltran</name></author><author><name sortKey="Massari, F" uniqKey="Massari F">F Massari</name></author><author><name sortKey="Maclennan, Gt" uniqKey="Maclennan G">GT MacLennan</name></author><author><name sortKey="Montironi, R" uniqKey="Montironi R">R Montironi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Long, Gv" uniqKey="Long G">GV Long</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rangwala, R" uniqKey="Rangwala R">R Rangwala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rebecca, Vw" uniqKey="Rebecca V">VW Rebecca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, D" uniqKey="Chen D">D Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roczniak Ferguson, A" uniqKey="Roczniak Ferguson A">A Roczniak-Ferguson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emanuel, R" uniqKey="Emanuel R">R Emanuel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spender, Lc" uniqKey="Spender L">LC Spender</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kabeya, Y" uniqKey="Kabeya Y">Y Kabeya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name></author><author><name sortKey="Pattingre, S" uniqKey="Pattingre S">S Pattingre</name></author><author><name sortKey="Sinha, S" uniqKey="Sinha S">S Sinha</name></author><author><name sortKey="Bassik, M" uniqKey="Bassik M">M Bassik</name></author><author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franken, Na" uniqKey="Franken N">NA Franken</name></author><author><name sortKey="Rodermond, Hm" uniqKey="Rodermond H">HM Rodermond</name></author><author><name sortKey="Stap, J" uniqKey="Stap J">J Stap</name></author><author><name sortKey="Haveman, J" uniqKey="Haveman J">J Haveman</name></author><author><name sortKey="Van Bree, C" uniqKey="Van Bree C">C van Bree</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Streit, M" uniqKey="Streit M">M Streit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anders, S" uniqKey="Anders S">S Anders</name></author><author><name sortKey="Huber, W" uniqKey="Huber W">W Huber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kani, K" uniqKey="Kani K">K Kani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Love, Mi" uniqKey="Love M">MI Love</name></author><author><name sortKey="Huber, W" uniqKey="Huber W">W Huber</name></author><author><name sortKey="Anders, S" uniqKey="Anders S">S Anders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mootha, Vk" uniqKey="Mootha V">VK Mootha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Punj, V" uniqKey="Punj V">V Punj</name></author><author><name sortKey="Matta, H" uniqKey="Matta H">H Matta</name></author><author><name sortKey="Chaudhary, Pm" uniqKey="Chaudhary P">PM Chaudhary</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Anhui</li><li>Californie</li></region><settlement><li>Hefei</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Li, Shun" sort="Li, Shun" uniqKey="Li S" first="Shun" last="Li">Shun Li</name></region><name sortKey="Akbari, Omid" sort="Akbari, Omid" uniqKey="Akbari O" first="Omid" last="Akbari">Omid Akbari</name><name sortKey="Guo, Hongrui" sort="Guo, Hongrui" uniqKey="Guo H" first="Hongrui" last="Guo">Hongrui Guo</name><name sortKey="Hagiya, Ashley" sort="Hagiya, Ashley" uniqKey="Hagiya A" first="Ashley" last="Hagiya">Ashley Hagiya</name><name sortKey="In, Gino K" sort="In, Gino K" uniqKey="In G" first="Gino K." last="In">Gino K. In</name><name sortKey="Jang, Gyu Beom" sort="Jang, Gyu Beom" uniqKey="Jang G" first="Gyu-Beom" last="Jang">Gyu-Beom Jang</name><name sortKey="Liang, Chengyu" sort="Liang, Chengyu" uniqKey="Liang C" first="Chengyu" last="Liang">Chengyu Liang</name><name sortKey="Maazi, Hadi" sort="Maazi, Hadi" uniqKey="Maazi H" first="Hadi" last="Maazi">Hadi Maazi</name><name sortKey="Machida, Keigo" sort="Machida, Keigo" uniqKey="Machida K" first="Keigo" last="Machida">Keigo Machida</name><name sortKey="Peng, David" sort="Peng, David" uniqKey="Peng D" first="David" last="Peng">David Peng</name><name sortKey="Punj, Vasu" sort="Punj, Vasu" uniqKey="Punj V" first="Vasu" last="Punj">Vasu Punj</name><name sortKey="Punj, Vasu" sort="Punj, Vasu" uniqKey="Punj V" first="Vasu" last="Punj">Vasu Punj</name><name sortKey="Quach, Christine" sort="Quach, Christine" uniqKey="Quach C" first="Christine" last="Quach">Christine Quach</name><name sortKey="Sands, Nathaniel A" sort="Sands, Nathaniel A" uniqKey="Sands N" first="Nathaniel A." last="Sands">Nathaniel A. Sands</name><name sortKey="Song, Ying" sort="Song, Ying" uniqKey="Song Y" first="Ying" last="Song">Ying Song</name><name sortKey="Yang, Yongfei" sort="Yang, Yongfei" uniqKey="Yang Y" first="Yongfei" last="Yang">Yongfei Yang</name><name sortKey="Yu, Min" sort="Yu, Min" uniqKey="Yu M" first="Min" last="Yu">Min Yu</name><name sortKey="Yuan, Weiming" sort="Yuan, Weiming" uniqKey="Yuan W" first="Weiming" last="Yuan">Weiming Yuan</name><name sortKey="Zhao, Shihui" sort="Zhao, Shihui" uniqKey="Zhao S" first="Shihui" last="Zhao">Shihui Zhao</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Li, Shun" sort="Li, Shun" uniqKey="Li S" first="Shun" last="Li">Shun Li</name></noRegion><name sortKey="Guo, Hongrui" sort="Guo, Hongrui" uniqKey="Guo H" first="Hongrui" last="Guo">Hongrui Guo</name><name sortKey="Liu, Qingsong" sort="Liu, Qingsong" uniqKey="Liu Q" first="Qingsong" last="Liu">Qingsong Liu</name><name sortKey="Tang, Liling" sort="Tang, Liling" uniqKey="Tang L" first="Liling" last="Tang">Liling Tang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000313 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000313 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6461621
|texte= Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30979895" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |